Rahul Deo, MD, PhD

ASSOC ADJ PROF-FY
[email protected]
+1 415 514-0992

Dr. Rahul Deo was born and raised in Canada and earned his medical degree from Cornell University Medical College and PhD in Molecular Biophysics from the Rockefeller University as part of the Tri-Institutional MD-PhD Program. He completed his internship and residency in Internal Medicine at Brigham and Women’s Hospital and Cardiology Fellowship at the Massachusetts General Hospital. He then conducted postdoctoral research in human genetics and computational biology at Harvard Medical School. Dr. Deo’s clinical and research interests involve bringing large-scale genetic and genomic data and emerging computational approaches towards the goal of personalized diagnosis and therapy in cardiovascular medicine. He focuses on patients with inherited cardiovascular disease, particularly cardiomyopathies.

Medical School: Weill Medical College of Cornell University
Graduate School: The Rockefeller University
Residency: Brigham and Women’s Hospital
Fellowship: Massachusetts General Hospital

Certifications:
- Internal Medicine 2006
- Cardiology 2010

Publications: 

Recommendations for Statistical Reporting in Cardiovascular Medicine: A Special Report From the American Heart Association.

Circulation

Althouse AD, Below JE, Claggett BL, Cox NJ, de Lemos JA, Deo RC, Duval S, Hachamovitch R, Kaul S, Keith SW, Secemsky E, Teixeira-Pinto A, Roger VL, American Heart Association Scientific Publishing Committee Statistics Task Force

A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy.

Nature communications

Huda A, Castaño A, Niyogi A, Schumacher J, Stewart M, Bruno M, Hu M, Ahmad FS, Deo RC, Shah SJ

Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms.

Nature communications

Goto S, Mahara K, Beussink-Nelson L, Ikura H, Katsumata Y, Endo J, Gaggin HK, Shah SJ, Itabashi Y, MacRae CA, Deo RC

Ecosystem Barriers to Innovation Adoption in Clinical Practice.

Trends in molecular medicine

MacRae CA, Deo RC, Shaw SY

Recommendations for Reporting Machine Learning Analyses in Clinical Research.

Circulation. Cardiovascular quality and outcomes

Stevens LM, Mortazavi BJ, Deo RC, Curtis L, Kao DP

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.

Nature structural & molecular biology

Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC

Proposed Requirements for Cardiovascular Imaging-Related Machine Learning Evaluation (PRIME): A Checklist: Reviewed by the American College of Cardiology Healthcare Innovation Council.

JACC. Cardiovascular imaging

Sengupta PP, Shrestha S, Berthon B, Messas E, Donal E, Tison GH, Min JK, D'hooge J, Voigt JU, Dudley J, Verjans JW, Shameer K, Johnson K, Lovstakken L, Tabassian M, Piccirilli M, Pernot M, Yanamala N, Duchateau N, Kagiyama N, Bernard O, Slomka P, Deo R, Arnaout R

Moving Genomics to Routine Care: An Initial Pilot in Acute Cardiovascular Disease.

Circulation. Genomic and precision medicine

Aryan Z, Szanto A, Pantazi A, Reddi T, Rheinstein C, Powers W, Wilson E, Deo RC, Chowdhury S, Salz L, Dimmock D, Nahas S, Benson W, Kingsmore SF, MacRae CA, Vuzman D

An International Multi-Center Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2- Catecholaminergic Polymorphic Ventricular Tachycardia.

Circulation

Ng K, Titus EW, Lieve KV, Roston TM, Mazzanti A, Deiter FH, Denjoy I, Ingles J, Till J, Robyns T, Connors SP, Steinberg C, Abrams DJ, Pang B, Scheinman MM, Bos JM, Duffett SA, van der Werf C, Maltret A, Green MS, Rutberg J, Balaji S, Cadrin-Tourigny J, Orland KM, Knight LM, Brateng C, Wu J, Tang AS, Skanes AC, Manlucu J, Healey JS, January CT, Krahn AD, Collins KK, Maginot KR, Fischbach P, Etheridge SP, Eckhardt LL, Hamilton RM, Ackerman MJ, Rosés I Noguer F, Semsarian C, Jura N, Leenhardt A, Gollob MH, Priori SG, Sanatani S, Wilde AAM, Deo RC, Roberts JD

Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary.

Circulation

Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB

A Novel Role for Piezo1 in Diabetes-Associated Thrombosis.

Biophysical Journal

Wandi Zhu, Cissy Nsubuga, Shane Wright, Manu Beerens, Tuomas Kiviniemi, Vanessa Raskin, Rahul C. Deo, Calum A. MacRae

Coronary Microvascular Dysfunction, Left Ventricular Remodeling and Clinical Outcomes in Patients with Chronic Kidney Impairment.

Circulation

Bajaj NS, Singh A, Zhou W, Gupta A, Fujikura K, Byrne C, Harms HJ, Osborne MT, Bravo P, Andrikopoulou E, Divakaran S, Bibbo CF, Hainer J, Skali H, Taqueti V, Steigner M, Dorbala S, Charytan DM, Prabhu SD, Blankstein R, Deo RC, Solomon SD, Di Carli MF

Automated and Interpretable Patient ECG Profiles for Disease Detection, Tracking, and Discovery.

Circulation. Cardiovascular quality and outcomes

Tison GH, Zhang J, Delling FN, Deo RC

Coronary Arteries and the Cell Count.

Circulation

Divanji P, Deo R, Harris I

Fully Automated Echocardiogram Interpretation in Clinical Practice.

Circulation

Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC

MAGUS: A Shared Tool for the Genetic Community.

Circulation. Cardiovascular quality and outcomes

Golbus JR, Nallamothu BK, Deo RC

A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.

Developmental cell

Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR

Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Cell

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Diabetes

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Stem cell reports

Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Cell stem cell

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA

Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction.

Journal of cardiovascular translational research

Katz DH, Deo RC, Aguilar FG, Selvaraj S, Martinez EE, Beussink-Nelson L, Kim KA, Peng J, Irvin MR, Tiwari H, Rao DC, Arnett DK, Shah SJ

Bundle Branch Re-Entrant Ventricular Tachycardia: Novel Genetic Mechanisms in a Life-Threatening Arrhythmia.

JACC. Clinical electrophysiology

Roberts JD, Gollob MH, Young C, Connors SP, Gray C, Wilton SB, Green MS, Zhu DW, Hodgkinson KA, Poon A, Li Q, Orr N, Tang AS, Klein GJ, Wojciak J, Campagna J, Olgin JE, Badhwar N, Vedantham V, Marcus GM, Kwok PY, Deo RC, Scheinman MM

Learning About Machine Learning: The Promise and Pitfalls of Big Data and the Electronic Health Record.

Circulation. Cardiovascular quality and outcomes

Deo RC, Nallamothu BK

Perinatal Licensing of Thermogenesis by IL-33 and ST2.

Cell

Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A

Machine Learning in Medicine.

Circulation

Deo RC

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.

eLife

Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC

Exome sequencing in suspected monogenic dyslipidemias.

Circulation. Cardiovascular genetics

Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S

RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.

Circulation research

Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D

Prioritizing causal disease genes using unbiased genomic features.

Genome biology

Deo RC, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP

Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.

Circulation. Cardiovascular genetics

Roberts JD, Longoria J, Poon A, Gollob MH, Dewland TA, Kwok PY, Olgin JE, Deo RC, Marcus GM

Phenomapping for novel classification of heart failure with preserved ejection fraction.

Circulation

Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo RC

Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.

JAMA neurology

Mak AC, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz JM, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Duncan JL, Miller BL, Kane JP, Kwok PY, Malloy MJ

Phenotypic spectrum of heart failure with preserved ejection fraction.

Heart failure clinics

Shah SJ, Katz DH, Deo RC

Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

Cell

Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.

Nature

Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, Rolland T, Grace M, Dricot A, Askenazi M, Tavares M, Pevzner SJ, Abderazzaq F, Byrdsong D, Carvunis AR, Chen AA, Cheng J, Correll M, Duarte M, Fan C, Feltkamp MC, Ficarro SB, Franchi R, Garg BK, Gulbahce N, Hao T, Holthaus AM, James R, Korkhin A, Litovchick L, Mar JC, Pak TR, Rabello S, Rubio R, Shen Y, Singh S, Spangle JM, Tasan M, Wanamaker S, Webber JT, Roecklein-Canfield J, Johannsen E, Barabási AL, Beroukhim R, Kieff E, Cusick ME, Hill DE, Münger K, Marto JA, Quackenbush J, Roth FP, DeCaprio JA, Vidal M

Programming human pluripotent stem cells into white and brown adipocytes.

Nature cell biology

Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA

Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue.

PloS one

Lau FH, Deo RC, Mowrer G, Caplin J, Ahfeldt T, Kaplan A, Ptaszek L, Walker JD, Rosengard BR, Cowan CA

Identification of adult nephron progenitors capable of kidney regeneration in zebrafish.

Nature

Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

PloS one

Deo RC, Wilson JG, Xing C, Lawson K, Kao WH, Reich D, Tandon A, Akylbekova E, Patterson N, Mosley TH, Boerwinkle E, Taylor HA

Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish.

Disease models & mechanisms

Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA

Clinical screening and genetic testing.

Clinics in laboratory medicine

Deo RC, MacRae CA

The zebrafish: scalable in vivo modeling for systems biology.

Wiley interdisciplinary reviews. Systems biology and medicine

Deo RC, MacRae CA

Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.

Circulation. Cardiovascular genetics

Keebler ME, Deo RC, Surti A, Konieczkowski D, Guiducci C, Burtt N, Buxbaum SG, Sarpong DF, Steffes MW, Wilson JG, Taylor HA, Kathiresan S

Metabolic signatures of exercise in human plasma.

Science translational medicine

Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE

Clinical screening and genetic testing.

Heart failure clinics

Deo RC, MacRae CA

Interpreting metabolomic profiles using unbiased pathway models.

PLoS computational biology

Deo RC, Hunter L, Lewis GD, Pare G, Vasan RS, Chasman D, Wang TJ, Gerszten RE, Roth FP

An admixture scan in 1,484 African American women with breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Fejerman L, Haiman CA, Reich D, Tandon A, Deo RC, John EM, Ingles SA, Ambrosone CB, Bovbjerg DH, Jandorf LH, Davis W, Ciupak G, Whittemore AS, Press MF, Ursin G, Bernstein L, Huntsman S, Henderson BE, Ziv E, Freedman ML

Pathways of the heart.

Circulation. Cardiovascular genetics

Deo RC, Roth FP

Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

PLoS genetics

Deo RC, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, Kathiresan S, Sarpong D, Taylor HA, Wilson JG

The genetics of cardiomyopathies: what clinicians should know.

Current heart failure reports

Deo R, MacRae CA

A high-density admixture scan in 1,670 African Americans with hypertension.

PLoS genetics

Deo RC, Patterson N, Tandon A, McDonald GJ, Haiman CA, Ardlie K, Henderson BE, Henderson SO, Reich D

Structural bases for CRMP function in plexin-dependent semaphorin3A signaling.

The EMBO journal

Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM

TBX5 nuclear localization is mediated by dual cooperative intramolecular signals.

Journal of molecular and cellular cardiology

Collavoli A, Hatcher CJ, He J, Okin D, Deo R, Basson CT

X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.

Proceedings of the National Academy of Sciences of the United States of America

Deo RC, Sonenberg N, Burley SK

Translational repression by a novel partner of human poly(A) binding protein, Paip2.

Molecular cell

Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N

Recognition of polyadenylate RNA by the poly(A)-binding protein.

Cell

Deo RC, Bonanno JB, Sonenberg N, Burley SK