Nadia Roan, PhD

Professor in Residence
M_Urology
+1 415 734-4883

The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. We have demonstrated that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells through at least two distinct mechanisms: promoting viral entry, and altering the cellular state of T cells to render them more permissive to viral replication. To characterize the molecular basis of how intrinsic and extrinsic perturbations can render some subsets of CD4+ T cells more susceptible than others to HIV infection, we are using a variety of global gene expression analysis approaches, including CyTOF and RNA-seq. These approaches are also being used to characterize the HIV latent reservoir and the nature of viral rebound upon antiretroviral treatment interruption. Another research interest in the lab is to understand how factors in seminal plasma affect reproductive health and susceptibility to sexually transmitted diseases.

Publications

Targeting the SARS-CoV-2 reservoir in long COVID.

The Lancet. Infectious diseases

Proal AD, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow DS, Davies HE, Dupont CL, Deeks SG, Ely EW, Fasano A, Freire M, Geng LN, Griffin DE, Henrich TJ, Hewitt SM, Iwasaki A, Krumholz HM, Locci M, Marconi VC, Mehandru S, Muller-Trutwin M, Painter MM, Pretorius E, Price DA, Putrino D, Qian Y, Roan NR, Salmon D, Tan GS, VanElzakker MB, Wherry EJ, Van Weyenbergh J, Yonker LM, Peluso MJ

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions.

Frontiers in Systems Biology

Jun Sun, Masanori Aikawa, Hassan Ashktorab, Noam D. Beckmann, Michael L. Enger, Joaquin M. Espinosa, Xiaowu Gai, Benjamin D. Horne, Paul Keim, Jessica Lasky-Su, Rebecca Letts, Cheryl L. Maier, Meisha Mandal, Lauren Nichols, Nadia R. Roan, Mark W. Russell, Jacqueline Rutter, George R. Saade, Kumar Sharma, Stephanie Shiau, Stephen N. Thibodeau, Samuel Yang, Lucio Miele, NIH Researching COVID to Enhance Recovery Consortium

Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.

Nature communications

Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky SM, Witt MD, Post WS, Kossenkov A, Landay AL, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M

HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.

Viruses

Danielle E. Lyons, Priti Kumar, Nadia R. Roan, Patricia A. Defechereux, Cedric Feschotte, Ulrike C. Lange, Niren Murthy, Pauline Sameshima, Eric Verdin, Julie A. Ake, Matthew S. Parsons, Avindra Nath, Sara Gianella, Davey M. Smith, Esper G. Kallas, Thomas J. Villa, Richard Strange, Betty Mwesigwa, Robert L. Furler O’Brien, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana T. Valente, Melanie Ott

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.

Nature

Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.

JAMA

anayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Mary L. Disis, George J. Disis, RECOVER Consortium Authors, Leora I. Horwitz, Andrea S. Foulkes, Judith A. Aberg, Natalie L. Adolphi, Shreya Ahirwar, Shifa Ahmed, Neera Ahuja, Masanori Aikawa, Almary Akerlundh, Teresa T. Akintonwa, Aseel Al-Jadiri, Natalya Alekhina, Heather A. Algren, Akram N. Alshawabkeh, Nariman Ammar, Adit Anand, Brett R. Anderson, Lisa Aponte-Soto, Judy L. Aschner, Mary M. Atha, Andrew M. Atz, Robin L. Aupperle, Mirna Ayache, Eduardo Azziz-Baumgartner, L. C. Bailey, Fiona C. Baker, Venkataraman Balaraman, Jennifer A. Bandy, Dithi Banerjee, Deanna M. Barch, James M. Bardes, Jackson Barlocker, R. G. Barr, Arielle Baskin-Sommers, Sanjib Basu, Tracy A. Battaglia, Leah Baucom, Carmen J. Beamon, Casey L. Beaty, Noam D. Beckmann, Jasmine A. Berry, Nahid Bhadelia, Daksh Bhargava, Bhuiyan, Jiang Bian, Christian Bime, James M. Bjork, Lora J. Black, Catherine A. Blish, Jason P. Block, Amanda Bogie, Dawn Bolliger, William Bonaventura, Seuli Bose-Brill, Mary B. Bower, Andrew D. Boyd, Jerusha Boyineni, Steven B. Bradfute, Carolyn T. Bramante, M. D. Brannock, J. D. Bremner, Shari B. Brosnahan, Natalie C. Buchbinder, Elliott Bueler, Irina A. Buhimschi, Hulya Bukulmez, H. T. Bunnell, John B. Buse, Elizabeth A. Calhoun, Tingyi Cao, Michael D. Carrithers, Thomas W. Carton, Abigail Case, B.J. Casey, Faye Victoria C. Casimero, Lauren Castro, Teresa Cato, Patricia Ceger, Connie L. Cerullo, Linda Chang, Arunee A. Chang, Praneeth Chebrolu, Yong Chen, Li Qing Chen, Benjamin K. Chen, David Chestek, Robert F. Chew, Deena J. Chisolm, Dominic C. Chow, Maryanne R. Chrisant, Dimitri A. Christakis, Christopher G. Chute, Mine S. Cicek, Cheryl R. Clark, Duncan B. Clark, Geoffrey D. Clarke, Katharine N. Clouser, Thomas J. Connors, Judith A. Cook, Krista Coombs, Carlos Cordon-Cardo, Julie L. Costello, Lesley Cottrell, Kelly Cowan, Lindsay G. Cowell, Savannah Cranford, Jamie Cronin, Mollie R. Cummins, Hannah L. Curry, Viren D'Sa, Sean G. Dabney, Casey L. Daniel, Mirella Dapretto, Dawood Darbar, Paul M. Darden, Raktima Dasgupta, Soham Dasgupta, Felicia Davis Blakley, Katherine Dea, Sara J. Deakyne Davies, Lauren A. Decker, Ralph A. DeFronzo, Walter Dehority, Amelia N. Deitchman, James del Alcazar, Phoebe Del Boccio, Carlos del Rio, Marina Del Rios, Julie A. DeLisa, Sean C. Deoni, Maya Z. Diaz, John D. Dickinson, Audrey Dionne, Kathleen R. Diviak, Sarah E. Donohue, Michael J. Downey, Allen J. Dozor, Benard P. Dreyer, Kirsten B. Dummer, Matthew S. Durstenfeld, Mark S. Dworkin, Sherrie L. Edmonds, Matthew D. Elias, Jamie Elifritz, Evan Ellingworth, Amy J. Elliott, Angela M. Ellison, Mike L. Enger, Joaquin M. Espinosa, Shari Esquenazi-Karonika, Michael D. Evans, Danielle N. Evans, Julio C. Facelli, Camila S. Fang, E. Vincent S. Faustino, Maria E. Fayad Lara, Candace H. Feldman, Alexander G. Fiks, Rebecca Fineman, Aloke V. Finn, Melinda S. Fischer, Megan L. Fitzgerald, Valerie J. Flaherman, Thomas J. Flotte, Daniel Forsha, Meghan R. Fortune, John J. Foxe, Nicole Franks, Michael B. Freedman, Catherine E. Freeland, Naomi P. Friedman, Greta Fry, Margot Gage Witvliet, Emily J. Gallagher, Richard Gallagher, Hugh Garavan, Sunanda M. Gaur, Dylan G. Gee, Maria Laura Gennaro, Lynn B. Gerald, Saikat B. Ghosh, Joseph T. Giacino, Andrew T. Girvin, Stephanie L. Godfrey, Mark P. Goldberg, Steven N. Goodman, Howard S. Gordon, Ramkiran Gouripeddi, Paige Graham, Joey P. Granger, Kevin M. Gray, Tina Greimes, Rachel S. Gross, Nicholas Guthe, Evan Gutter, Stephanie Haasnoot, Emily C. Hadley, Melissa A. Haendel, Stephanie Hafner, Katia C. Halabi, Patrick C. Hanley, Ashraf S. Harahsheh...