Mark Looney, MD

Professor In Residence
Medicine
[email protected]
+1 415 476-9190

Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

Research Interests

My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

Publications: 

(225) Novel Anti-CD94 Treatment Reduces Mouse and Human Experimental Pulmonary Ischemia-Reperfusion Injury.

The Journal of Heart and Lung Transplantation

T. Tsao, L. Qiu, A. Shemesh, A. Millan Hernandez, K. Shi, J. Richardson, R. Bharti, J. Santos, L. Lanier, M. Looney, J. Greenland, D.R. Calabrese

IgG hexamers initiate complement-dependent acute lung injury.

The Journal of clinical investigation

Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR

Functional haematopoietic progenitor cells in the adult human lung.

Research square

Looney M, Conrad C, Magnen M, Tsui J, Wismer H, Naser M, Venkataramani U, Samad B, Cleary S, Qiu L, Tian J, De Giovanni M, Mende N, Passegue E, Laurenti E, Combes A

IgG hexamers initiate acute lung injury.

bioRxiv : the preprint server for biology

Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR

MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death.

American journal of respiratory and critical care medicine

Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators

CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury.

JCI insight

Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR

B-075 Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis.

Clinical chemistry

M Sorrells, Y Seo, M Magnen, R Sheybani, A M Shah, H T Tse, M R Looney, H O'Neal

Optimizing anesthesia and delivery approaches for dosing into lungs of mice.

American journal of physiology. Lung cellular and molecular physiology

Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ

Optimizing anesthesia and delivery approaches for dosing into lungs of mice.

bioRxiv : the preprint server for biology

Seo Y, Qiu L, Magnen M, Conrad C, Moussavi-Harami SF, Looney MR, Cleary SJ

Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis.

Diagnostics (Basel, Switzerland)

Sorrells MG, Seo Y, Magnen M, Broussard B, Sheybani R, Shah AM, O'Neal HR, Tse HTK, Looney MR, Di Carlo D

CCR5 Mediates Natural Killer Cell Airway Trafficking in Lung Ischemia Reperfusion Injury.

The Journal of Heart and Lung Transplantation

J. Santos, S. Cleary, P. Wang, A. Shemesh, T. Tsao, E. Aminian, M.R. Looney, J.R. Greenland, D.R. Calabrese

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

Stem cell reports

Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.

JCI insight

Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR

Is neutrophilic inflammation treatable in COVID-19?

The Lancet. Respiratory medicine

Conrad C, Looney MR

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.

American journal of respiratory cell and molecular biology

Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Research square

Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M

Immediate myeloid depot for SARS-CoV-2 in the human lung.

bioRxiv : the preprint server for biology

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR

Transfusion-Related Acute Lung Injury: 36 years of Progress (1985-2021).

Annals of the American Thoracic Society

Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA

Bronchoalveolar Lavage MICB is Associated with Severe Primary Graft Dysfunction, Prolonged Mechanical Ventilation, and Low Post-Transplant FEV1 in Lung Transplant Recipients.

The Journal of Heart and Lung Transplantation

D.R. Calabrese, J.P. Singer, S.R. Hays, L.E. Leard, J.A. Golden, N.A. Kolaitis, M. Kleinhenz, R. Shah, A. Venado, J. Kukreja, J.A. Belperio, S.S. Weigt, J.R. Greenland, M.R. Looney

Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.

The Journal of clinical investigation

Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Mendez-Ferrer S, Swirski FK, Looney MR

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

Cell

De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG

CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.

Science (New York, N.Y.)

Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG

GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

Cell

De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG

ADAM8 signaling drives neutrophil migration and ARDS severity.

JCI insight

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology

Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G

In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.

ACS central science

Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS

Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.

Nature

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF

Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.

Proceedings of the National Academy of Sciences of the United States of America

Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S

Natural Killer Cells Recognize Pulmonary Epithelial Stress Molecules during Primary Graft Dysfunction.

The Journal of Heart and Lung Transplantation

E. Aminian, B. Mallavia, F. Liu, S. Cleary, P. Wang, J.P. Singer, S.R. Hays, J.A. Golden, J. Kukreja, D. Dugger, M. Nakamura, L.L. Lanier, M.R. Looney, J.R. Greenland, D.R. Calabrese

Chewing the fat on TRALI.

Blood

Cleary SJ, Looney MR

Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.

The Journal of clinical investigation

Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR

ß2M Signals Monocytes Through Non-Canonical TGFß Receptor Signal Transduction.

Circulation research

Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath K, Morrell C

Global absence and targeting of protective immune states in severe COVID-19.

Nature

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S

Lung megakaryocytes are immune modulatory cells.

The Journal of clinical investigation

Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders Ii J, Georas SN, Veazey JM, Madere F, Tesoro Santos L, Arne AM, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons CE, Metcalf Pate KA, McGrath KE, Palis J, Morrell C

Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation.

Science advances

Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS

Complement activation on endothelium initiates antibody-mediated acute lung injury.

The Journal of clinical investigation

Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR

Update on animal models for COVID-19 research.

British journal of pharmacology

Cleary SJ, Magnen M, Looney MR, Page CP

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

bioRxiv : the preprint server for biology

Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

Research square

Krummel M, Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, Cleary S, Chew N, Kushnoor D, Reeder G, Shen A, Tsui J, Hiam K, Sandoval PM, Zhu W, Lee D, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik C, Loudermilk R, Wilson M, Ye C, Fragiadakis G, Looney M, Chan V, Ward A, Carrillo S, Matthay M, Erle D, Woodruff P, Langelier C, Kangelaris K, Hendrickson C, Calfee C, Rao A

Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose.

Archives of toxicology

Zhao Y, Magaña LC, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L

NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.

Transfusion

Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL

Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.

British journal of pharmacology

Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

The Journal of experimental medicine

Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.

The Journal of clinical investigation

Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR

Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction.

American journal of respiratory cell and molecular biology

Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch Iii JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR

Platelet Biogenesis in the Lung Circulation.

Physiology (Bethesda, Md.)

Lefrançais E, Looney MR

Modulating pathogenesis with Mobile-CRISPRi.

Journal of bacteriology

Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS

LPS-Induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-selectin.

American journal of respiratory cell and molecular biology

Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC

An update of the transfusion-related acute lung injury (TRALI) definition.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

American journal of respiratory and critical care medicine

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV

A consensus redefinition of transfusion-related acute lung injury.

Transfusion

Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S

Live imaging of the pulmonary immune environment.

Cellular immunology

Looney MR, Headley MB

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Research and practice in thrombosis and haemostasis

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H

Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

Critical care medicine

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.

JCI insight

Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR

Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway.

American journal of respiratory and critical care medicine

Lefrançais E, Looney MR

Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

JCI insight

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR

Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Transfusion

Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

Science immunology

Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P

Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training.

Annals of the American Thoracic Society

Santhosh L, Babik J, Looney MR, Hollander H

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.

Nature

Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR

Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

Thorax

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM

Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies.

Shock (Augusta, Ga.)

Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR

Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.

Vox sanguinis

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL

Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response.

Nature communications

Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

The Journal of experimental medicine

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG

Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules.

Annals of the American Thoracic Society

Henry TS, Naeger DM, Looney MR, Elicker BM

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis.

JCI insight

Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ

Reply to concerns regarding dropping the term "possible TRALI".

Transfusion

Toy P, Kleinman SH, Looney MR

Visualization of immediate immune responses to pioneer metastatic cells in the lung.

Nature

Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF

Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Mallavia B, Liu F, Sheppard D, Looney MR

Selectin' for NETs.

Blood

Looney MR

Non-invasive Intratracheal Instillation in Mice.

Bio-protocol

Ortiz-Muñoz G, Looney MR

Two-event Transfusion-related Acute Lung Injury Mouse Model.

Bio-protocol

Ortiz-Muñoz G, Looney MR

Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation.

American journal of respiratory and critical care medicine

Sayah DM, Mallavia B, Looney MR

Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.

PloS one

Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Transfusion

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL

Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.

American journal of respiratory and critical care medicine

Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Nature

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Transfusion

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR

Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction.

Respiratory research

Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Critical care medicine

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P

The spatiotemporal cellular dynamics of lung immunity.

Trends in immunology

Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF

Live imaging of the lung.

Annual review of physiology

Looney MR, Bhattacharya J

Risk factors and outcomes in transfusion-associated circulatory overload.

The American journal of medicine

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.

The Journal of clinical investigation

Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.

The Journal of experimental medicine

Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF

Live imaging of the lung.

Current protocols in cytometry

Thornton EE, Krummel MF, Looney MR

Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.

Anesthesia and analgesia

Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA

Transfusion-related acute lung injury: incidence and risk factors.

Blood

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA

Reducing noninfectious risks of blood transfusion.

Anesthesiology

Gilliss BM, Looney MR, Gropper MA

Lung surveillance revealed by two-photon live imaging (103.3).

The Journal of Immunology

Emily Thornton, Mark Looney, Debasish Sen, Dean Sheppard, Xiaozhu Huang, Matthew Krummel

The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components.

Transfusion

Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM

Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA

Experimental models of transfusion-related acute lung injury.

Transfusion medicine reviews

Gilliss BM, Looney MR

Stabilized imaging of immune surveillance in the mouse lung.

Nature methods

Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF

Pathophysiology of transfusion-related acute lung injury.

Current opinion in hematology

Looney MR, Gilliss BM, Matthay MA

Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.

American journal of physiology. Lung cellular and molecular physiology

Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA

Inhaled activated protein C: a novel therapy for acute lung injury?

Critical care (London, England)

Liu KD, Looney MR, Matthay MA

Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury.

American journal of physiology. Lung cellular and molecular physiology

Su X, Looney MR, Gupta N, Matthay MA

Neutrophil sandwiches injure the microcirculation.

Nature medicine

Looney MR, Matthay MA

CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia.

Journal of immunology (Baltimore, Md. : 1950)

Su X, Johansen M, Looney MR, Brown EJ, Matthay MA

The role of protein C in sepsis.

Current infectious disease reports

Looney MR, Matthay MA

Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.

The FASEB Journal

Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay

Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature.

Transfusion medicine (Oxford, England)

Church GD, Price C, Sanchez R, Looney MR

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA

Animal models of transfusion-related acute lung injury.

Critical care medicine

Looney MR, Matthay MA

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

American journal of physiology. Lung cellular and molecular physiology

Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA

Transfusion-related acute lung injury: a review.

Chest

Looney MR, Gropper MA, Matthay MA

The Role of Protein C in Sepsis.

Current infectious disease reports

Looney MR, Matthay MA