
Professor In Residence
M_MED-CORE-PULM
+1 415 514-2061
Research Interests
I. Mentoring in Translational Research
II. The identification of molecular sub-phenotypes of asthma and COPD
III. Mechanisms of airway inflammation and remodeling in lung diseases
IV. Development of blood-based diagnostic tests for lung disease using genomic approaches
V. Clinical Trials in asthma and COPD
Publications
A Four-gene CC16-associated Transcriptomic Score and Risk for Asthma Exacerbations.
American journal of respiratory and critical care medicine
Ambient Fine Particulate Matter Exposures, Platelet Activation and Respiratory Morbidity in COPD: The SPIROMICS Air Study.
American journal of respiratory and critical care medicine
Association of Contrast Enhanced Dual Energy CT-derived Pulmonary Arterial Tree-to-Lung Ratio (ArtLR) With COPD.
American journal of respiratory and critical care medicine
Association of a Novel Index of Early-life Growth Conditions With Chronic Obstructive Pulmonary Disease Phenotype and Prognosis.
American journal of respiratory and critical care medicine
Breathless Under Pressure: The Association Between Stress Levels and Symptom Burden in COPD Patients From the Spiromics Cohort.
American journal of respiratory and critical care medicine
Differences in Epithelial Gene Expression Profiles in Asthma Patients Living in Industrialized Cities With High PM2.5 and SO2 Exposures.
American journal of respiratory and critical care medicine
Food Desert Is Associated With All-cause and Cardiovascular Mortality in SPIROMICS.
American journal of respiratory and critical care medicine
Gene Expression Deconvolution of Hair Follicle Cells Demonstrates Lung-Relevant Cell Types. The Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
American journal of respiratory and critical care medicine
High Airway TSLP Levels in Asthma Associate With Higher Scores for Mucus Plugging and Air Trapping.
American journal of respiratory and critical care medicine
Plasma Metabolomics and Long-term Mortality in Current and Former Tobacco Cigarette Users by Lung Function Impairment: A SPIROMICS Analysis.
American journal of respiratory and critical care medicine
Race-neutral Lung Function Interpretation Does Not Alter Correlation to Symptom Burden in Asthma.
American journal of respiratory and critical care medicine
Single Nucleotide Variants in the Fc Receptor for IgG Are Associated With COPD Severity and Exacerbations in African American Participants From COPDGene and SPIROMICS.
American journal of respiratory and critical care medicine
The Size and Location Features of Mucus Plugs in COPD Differ Depending on the Extent of Emphysema.
American journal of respiratory and critical care medicine
Unraveling the Role of Cell-free DNA as a Biomarker in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations.
American journal of respiratory and critical care medicine
Associations of Pre-Pandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study.
American journal of respiratory and critical care medicine
Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort.
Annals of the American Thoracic Society
Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes.
Annals of the American Thoracic Society
Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study.
Open forum infectious diseases
Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.
Annals of the American Thoracic Society
Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.
American journal of respiratory and critical care medicine
Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed.
medRxiv : the preprint server for health sciences
Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.
medRxiv : the preprint server for health sciences
α1-Antitrypsin Gene Variation Associates with Asthma Exacerbations and Related Health Care Utilization.
The journal of allergy and clinical immunology. In practice
Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program.
bioRxiv : the preprint server for biology
MRI-assessed Dynamic Hyperinflation Induced by Tachypnea in Chronic Obstructive Pulmonary Disease: The SPIROMICS-HF Study.
Radiology. Cardiothoracic imaging
Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS.
American journal of respiratory and critical care medicine
Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma.
American journal of respiratory and critical care medicine
Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters.
American journal of respiratory cell and molecular biology
Association of Ground Glass Opacities with Systemic Inflammation and Progression of Emphysema.
American journal of respiratory and critical care medicine
Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan.
American journal of respiratory and critical care medicine
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.
American journal of respiratory and critical care medicine
Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts.
The Lancet. Respiratory medicine
Radiomultiomics: pioneering precision medicine for severe asthma.
The European respiratory journal
The Effect of Chronic Altitude Exposure on COPD Outcomes in the SPIROMICS Cohort.
American journal of respiratory and critical care medicine
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Nature communications
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma.
Research square
Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with COPD.
Annals of the American Thoracic Society
Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies.
The European respiratory journal
IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America
Dynamic and prognostic proteomic associations with FEV1 decline in chronic obstructive pulmonary disease.
medRxiv : the preprint server for health sciences
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in COPD.
American journal of respiratory and critical care medicine
Estimating ambient air pollutant concentrations outside and inside homes in the Subpopulations and Intermediate Outcomes in COPD Air Pollution (SPIROMICS Air) cohort.
Environmental research
Vessel and Airway Characteristics in One-Year CT-defined Rapid Emphysema Progression: SPIROMICS.
Annals of the American Thoracic Society
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Nature communications
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.
JCI insight
Epidemiologic Features of Recovery From SARS-CoV-2 Infection.
JAMA network open
A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma.
American journal of respiratory and critical care medicine
A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.
Nature communications
IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.
bioRxiv : the preprint server for biology
A novel DNase assay reveals low DNase activity in severe asthma.
American journal of physiology. Lung cellular and molecular physiology
Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma.
The Journal of allergy and clinical immunology
Airway tree caliber heterogeneity and airflow obstruction among older adults.
Journal of applied physiology (Bethesda, Md. : 1985)
Demographic and Clinical Factors Associated With SARS-CoV-2 Spike 1 Antibody Response Among Vaccinated US Adults: the C4R Study.
Nature communications
Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma.
JCI insight
Lung Structure and Risk of Sleep Apnea in SPIROMICS.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR.
American journal of respiratory and critical care medicine
Repeatability of Pulmonary Quantitative CT Measurements in COPD.
American journal of respiratory and critical care medicine
African American race is associated with worse sleep quality in heavy smokers.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Spirometry in Mixed Race Civil War Veterans.
Annals of the American Thoracic Society
Systemic Markers of Lung Function and FEV1 Decline across Diverse Cohorts.
Annals of the American Thoracic Society
Changes in Lung Volumes with Spirometric Disease Progression in COPD.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Impact of Marijuana Smoking on COPD Progression in a Cohort of Middle-Aged and Older Persons.
Chronic obstructive pulmonary diseases (Miami, Fla.)
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD.
Scientific reports
Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes.
The Journal of asthma : official journal of the Association for the Care of Asthma
Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS.
Clinical immunology (Orlando, Fla.)
An essential role for miR-15/16 in Treg suppression and restriction of proliferation.
bioRxiv : the preprint server for biology
Abstract P461: Changes in Cigarette Smoking Patterns During the COVID-19 Pandemic: The C4R Study.
Circulation
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
American journal of respiratory and critical care medicine
Bronchial Epithelial Cell Transcriptional Responses to Inhaled Corticosteroids Dictate Severe Asthmatic Outcomes.
The Journal of allergy and clinical immunology
Predicting severe chronic obstructive pulmonary disease exacerbations using quantitative CT: a retrospective model development and external validation study.
The Lancet. Digital health
Ambient Air Pollution Exposure and Sleep Quality in COPD.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.
Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation
Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS.
Respiratory research
The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma.
American journal of respiratory and critical care medicine
COVID-19-Associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine
Effect of marijuana smoking on lung function change in older ever tobacco smokers.
The European respiratory journal
Reply to: US Occupational Historical Perspective on Race and Lung Function.
American journal of respiratory and critical care medicine
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England)
Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function.
The New England journal of medicine
Reversible Airflow Obstruction Predicts Future COPD Development in the SPIROMICS Cohort.
American journal of respiratory and critical care medicine
Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage COPD.
American journal of respiratory and critical care medicine
Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity.
Sleep
Association Among Chronic Obstructive Pulmonary Disease Severity, Exacerbation Risk, and Anxiety and Depression Symptoms in the SPIROMICS Cohort.
Journal of the Academy of Consultation-Liaison Psychiatry
Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
American journal of epidemiology
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program.
Pediatric pulmonology
Mucus Plugs Persist in Asthma and Changes in Mucus Plugs Associate with Changes in Airflow Over Time.
American journal of respiratory and critical care medicine
Characterizing COPD Symptom Variability in the Stable State Utilizing the Evaluating Respiratory Symptoms in COPD Instrument.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Trends in prevalence of depression and anxiety symptoms and effects of sociodemographic variables before and after the first wave of COVID-19 in Qatar.
Journal of affective disorders
Reconsidering the Utility of Race-Specific Lung Function Prediction Equations.
American journal of respiratory and critical care medicine
The Type 2 Asthma Mediator IL-13 Inhibits SARS-CoV-2 Infection of Bronchial Epithelium.
American journal of respiratory cell and molecular biology
Ambient ozone effects on respiratory outcomes among smokers modified by neighborhood poverty: An analysis of SPIROMICS AIR.
The Science of The Total Environment
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology
Comparative Impact of Depressive Symptoms and Fev1% on Chronic Obstructive Pulmonary Disease.
Annals of the American Thoracic Society
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type-2 inflammation.
The Journal of clinical investigation
Clinically Significant and Comorbid Anxiety and Depressive Symptoms Predict Severe Respiratory Exacerbations in Smokers: A Post-Hoc Analysis of the COPDGene and SPIROMICS Cohorts.
Annals of the American Thoracic Society
Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease.
Respiratory research
Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences
Defining Resilience to Smoking Related Lung Disease: A Modified Delphi Approach from SPIROMICS.
Annals of the American Thoracic Society
Regulation of airway immunity by epithelial miRNAs.
Immunological reviews
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine
Update in Adult Asthma 2020.
American journal of respiratory and critical care medicine
High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis.
ERJ open research
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in SPIROMICS Study.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma.
The Journal of allergy and clinical immunology
Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
International journal of chronic obstructive pulmonary disease
Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
The Lancet. Respiratory medicine
Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD.
Respiratory research
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.
Respiratory research
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
Genome medicine
Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.
American journal of respiratory and critical care medicine
Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma.
American journal of respiratory and critical care medicine
Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
medRxiv : the preprint server for health sciences
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19.
bioRxiv : the preprint server for biology
Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.
Scientific reports
The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.
bioRxiv : the preprint server for biology
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.
NPJ biofilms and microbiomes
QCT-based Measures Of Airway Narrowing And Shape Changes Associated With Endobronchial Biopsy Tissue Measures of Airway Remodeling And Clinical Outcomes In Asthma.
Journal of Allergy and Clinical Immunology
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square
Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.
Scientific reports
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort.
International journal of chronic obstructive pulmonary disease
A randomised, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Design of the Redefining Therapy in Early COPD Study.
Chronic obstructive pulmonary diseases (Miami, Fla.)
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.
The Journal of allergy and clinical immunology
Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort.
International journal of chronic obstructive pulmonary disease
T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis.
Frontiers in immunology
COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids.
American journal of respiratory and critical care medicine
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.
Scientific reports
Long-term Sequelae of Nonobstructive Chronic Bronchitis-Is Airflow Obstruction Important?
JAMA internal medicine
A Randomized, Placebo-Controlled Trial Evaluating Effects of Lebrikizumab on Airway Eosinophilic Inflammation and Remodeling in Uncontrolled Asthma (CLAVIER).
The FASEB Journal
Efficient RNP-Directed Human Gene Targeting Reveals SPDEF is Required for IL-13-Induced Mucostasis.
American journal of respiratory cell and molecular biology
The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS.
American journal of respiratory and critical care medicine
Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.
JCI insight
T2-"Low" Asthma: Overview and Management Strategies.
The journal of allergy and clinical immunology. In practice
Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers.
JAMA internal medicine
Erratum: Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
Korean journal of radiology
Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis.
International journal of chronic obstructive pulmonary disease
An Expert Consensus Framework for Asthma Remission as a Treatment Goal.
The Journal of allergy and clinical immunology
CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis.
Respiratory medicine
Radiographic Lung Volumes Predict Progression to COPD in Smokers with Preserved Spirometry in SPIROMICS.
The European respiratory journal
A Genetic Risk Score Associated with COPD Susceptibility and Lung Structure on Computed Tomography.
American journal of respiratory and critical care medicine
Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.
Scientific reports
Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).
Respiratory research
Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers.
Korean journal of radiology
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.
The New England journal of medicine
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
American journal of respiratory and critical care medicine
Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.
Respiratory medicine
Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.
Journal of the American Heart Association
Safety and Tolerability of Comprehensive Research Bronchoscopy in COPD: Results from the SPIROMICS Bronchoscopy Sub-Study.
Annals of the American Thoracic Society
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nature genetics
A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.
American journal of respiratory and critical care medicine
Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Systemic markers of inflammation in smokers with symptoms despite preserved spirometry in SPIROMICS.
Chest
Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort.
Respiratory research
Targeting Chronic Obstructive Pulmonary Disease Phenotypes, Endotypes, and Biomarkers.
Annals of the American Thoracic Society
New Spirometry Indices for Detecting Mild Airflow Obstruction.
Scientific reports
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
The Journal of clinical investigation
Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.
JCI insight
Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Respiratory research
Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology
Genome-wide association study of lung function and clinical implication in heavy smokers.
BMC medical genetics
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology
Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials.
American journal of respiratory and critical care medicine
Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD.
Chest
Rural Residence and COPD Exacerbations: Analysis of the SPIROMICS Cohort.
Annals of the American Thoracic Society
At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine
NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort.
Respiratory medicine
Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.
The Journal of allergy and clinical immunology
ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues.
Genome biology
Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD.
Respiratory research
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
The Journal of clinical investigation
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
American journal of respiratory and critical care medicine
Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Chronic obstructive pulmonary diseases (Miami, Fla.)
Human airway branch variation and chronic obstructive pulmonary disease.
Proceedings of the National Academy of Sciences of the United States of America
Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.
The Lancet. Respiratory medicine
Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.
BMJ open respiratory research
The value of blood cytokines and chemokines in assessing COPD.
Respiratory research
Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.
The Journal of allergy and clinical immunology
Airway Mucin Concentration as a Marker of Chronic Bronchitis.
The New England journal of medicine
Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.
Journal of general internal medicine
American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.
American journal of respiratory and critical care medicine
Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.
The Lancet. Respiratory medicine
Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD).
Respiratory research
Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.
American journal of respiratory and critical care medicine
Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori.
Respiratory research
Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study.
BMJ open respiratory research
Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.
Annals of the American Thoracic Society
Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease.
The Journal of allergy and clinical immunology
Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.
American journal of respiratory and critical care medicine
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
American journal of respiratory and critical care medicine
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
Nature genetics
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.
American journal of respiratory and critical care medicine
Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity?
American journal of respiratory and critical care medicine
Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.
The Journal of allergy and clinical immunology
SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.
American journal of respiratory and critical care medicine
Tryptophan catabolism in acute exacerbations of chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease
Symptoms in Smokers with Preserved Pulmonary Function.
The New England journal of medicine
COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.
PloS one
Biomarkers in Severe Asthma.
Immunology and allergy clinics of North America
Alternative splicing of interleukin-33 and type 2 inflammation in asthma.
Proceedings of the National Academy of Sciences of the United States of America
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.
The Lancet. Respiratory medicine
IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells.
American journal of respiratory and critical care medicine
Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis.
American journal of respiratory and critical care medicine
Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function.
The New England journal of medicine
41 Asthma Pathogenesis and Phenotypes.
Murray and Nadel\u0027s Textbook of Respiratory Medicine
Future Research Directions in Asthma. An NHLBI Working Group Report.
American journal of respiratory and critical care medicine
Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.
The Journal of allergy and clinical immunology
Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management.
Lancet (London, England)
Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Journal of translational medicine
Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.
The European respiratory journal
Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy.
American journal of respiratory and critical care medicine
Update in asthma 2013.
American journal of respiratory and critical care medicine
Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma.
PloS one
Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
The New England journal of medicine
Serum IgE clearance is facilitated by human FceRI internalization.
The Journal of clinical investigation
Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study.
Journal of translational medicine
Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA.
Annals of the American Thoracic Society
Interferon-inducible chemokines reflect severity and progression in sarcoidosis.
Respiratory research
Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial.
The European respiratory journal
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.
The Journal of allergy and clinical immunology
A qPCR-based metric of Th2 airway inflammation in asthma.
Clinical and translational allergy
Double-edged sword?
JAMA internal medicine
Regulation and function of epithelial secreted phospholipase A2 group X in asthma.
American journal of respiratory and critical care medicine
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.
The Journal of allergy and clinical immunology
Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology
Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
Airway epithelial miRNA expression is altered in asthma.
American journal of respiratory and critical care medicine
Azithromycin and the risk of cardiovascular death.
The New England journal of medicine
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
The Journal of allergy and clinical immunology
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.
BMC medical genomics
Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Eri1 regulates microRNA homeostasis and mouse natural killer cell development and anti-viral function (115.9).
The Journal of Immunology
Function of the airway epithelium in asthma.
Journal of allergy
Azithromycin for prevention of exacerbations of COPD.
The New England journal of medicine
A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis.
American journal of respiratory and critical care medicine
Novel outcomes and end points: biomarkers in chronic obstructive pulmonary disease clinical trials.
Proceedings of the American Thoracic Society
Human asthma phenotypes: from the clinic, to cytokines, and back again.
Immunological reviews
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.
Journal of immunology (Baltimore, Md. : 1950)
The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation.
American journal of respiratory and critical care medicine
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.
Proceedings of the National Academy of Sciences of the United States of America
Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma.
The Journal of allergy and clinical immunology
DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
Journal of immunology (Baltimore, Md. : 1950)
iNKT cell subsets are associated with distinct clinical manifestations of pulmonary sarcoidosis. (37.16).
The Journal of Immunology
Molecular Th2 Phenotypes of Asthma: New Biomarker or NO?.
American journal of respiratory and critical care medicine
Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
American journal of respiratory and critical care medicine
Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine
T-helper type 2-driven inflammation defines major subphenotypes of asthma.
American journal of respiratory and critical care medicine
Divergent Roles for Airway Epithelial MMP7 and Retinoic Acid in Experimental Asthma (140.5).
The Journal of Immunology
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Nature immunology
Peripheral Biomarkers of an IL-13 Induced Bronchial Epithelial Gene Signature in Asthma.
Journal of Allergy and Clinical Immunology
Cognitive performance and grey matter density in psychosis: functional relevance of a structural endophenotype.
Neuropsychobiology
Prevalence and Risk Factors for Depressive Symptoms in Persons with Chronic Obstructive Pulmonary Disease.
Journal of general internal medicine
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.
The Journal of allergy and clinical immunology
Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease.
Journal of general internal medicine
Chapter 40 Chronic Obstructive Pulmonary Disease: Management of Chronic Disease.
Clinical Respiratory Medicine
Gene expression in asthmatic airway smooth muscle.
Proceedings of the American Thoracic Society
Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
American journal of respiratory and critical care medicine
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America
Quantitative morphology using bronchial biopsies.
European Respiratory Review
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction.
Chest
A distinctive alveolar macrophage activation state induced by cigarette smoking.
American journal of respiratory and critical care medicine
Dissecting asthma using focused transgenic modeling and functional genomics.
The Journal of allergy and clinical immunology
Methodologic advancements in the study of airway smooth muscle.
The Journal of allergy and clinical immunology
Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma
Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression.
American journal of respiratory and critical care medicine
Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens.
The Journal of allergy and clinical immunology
Insurance and quality of care for adults with acute asthma.
Journal of general internal medicine
X-ray absorption spectroscopy measurements of thin foil heating by Z-pinch radiation.
Physical review. E, Statistical, nonlinear, and soft matter physics
A prospective multicenter study of factors associated with hospital admission among adults with acute asthma.
The American journal of medicine
A prospective multicenter study of patient factors associated with hospital admission from the emergency department among children with acute asthma.
Archives of pediatrics & adolescent medicine
Airway remodeling in asthma.
Seminars in respiratory and critical care medicine
A role for neutrophils in asthma?
The American journal of medicine
Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects.
The Journal of allergy and clinical immunology
Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma.
The Journal of allergy and clinical immunology
Deep venous thrombosis in postoperative vascular surgical patients: a frequent finding without prophylaxis.
Journal of vascular surgery
Differences between men and women in reporting of symptoms during an asthma exacerbation.
Annals of emergency medicine
Relation between phase of menstrual cycle and emergency department visits for acute asthma.
American journal of respiratory and critical care medicine
Sudden-onset asthma exacerbations: clinical features, response to therapy, and 2-week follow-up. Multicenter Airway Research Collaboration (MARC) investigators.
The European respiratory journal
Elevated plasma eotaxin levels in patients with acute asthma.
The Journal of allergy and clinical immunology
Acute asthma among pregnant women presenting to the emergency department.
American journal of respiratory and critical care medicine
Effect of an emergency department asthma program on acute asthma care.
Annals of emergency medicine
Sex differences among adults presenting to the emergency department with acute asthma. Multicenter Asthma Research Collaboration Investigators.
Archives of internal medicine
Inhaled corticosteroids for asthma: are ED visits a missed opportunity for prevention?
The American journal of emergency medicine
A PROSPECTIVE MULTICENTER STUDY OF PRIMARY CARE PROVIDER STATUS AMONG CHILDREN PRESENTING TO THE EMERGENCY DEPARTMENT WITH ACUTE ASTHMA.
Pediatric Emergency Care
Sudden-onset severe acute asthma: clinical features and response to therapy.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
First episodes of psychosis in Afro-Caribbean and White people. An 18-year follow-up population-based study.
The British journal of psychiatry : the journal of mental science
Auditory hallucinations and perception of external speech.
Lancet (London, England)
Cortical response to exogenous visual stimulation during visual hallucinations.
Lancet (London, England)
Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration.
The New England journal of medicine
Results of 1000 kidney transplants in Brisbane.
Transplantation proceedings