Phyllis Tien, MD

PROF IN RES-HCOMP
M_MED-VAMC-INFD

Dr. Tien is Professor of Medicine at the University of California, San Francisco, and Chief of the Infectious Diseases Division at the San Francisco VA Health Care System. Her research program investigates how chronic viral infections—particularly HIV and HCV—and their associated metabolic and immune perturbations drive long-term organ injury in adults, with a primary focus on women.

She has held key national leadership roles, including Co-Chair of the Executive Committee and member of the Steering Committee for the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS), which unites two of the largest and longest-running NIH-funded prospective cohorts of adults with, and at risk for, HIV in the United States. Additional appointments include Chair of the Inter-CFAR Collaboration on HIV Research in Women; Chair of the External Scientific Advisory Committee for the NICHD-funded Pediatric HIV/AIDS Cohort Study; and membership on the Scientific Advisory Committee for the Study of Treatment and Reproductive Outcomes (STAR) in women with and without HIV, and the External Scientific Advisory Board for the Building Interdisciplinary Research Careers in Women's Health (BIRCWH) K12 Program at Emory University.

Her government and professional service includes chairing the NIH AIDS Clinical Epidemiology Study Section and serving on the Department of Health and Human Services Antiretroviral Guidelines Panel, the NIAID AIDS Research Study Section, the NIH COVID-19 Treatment Guidelines Panel, and the Infectious Diseases Society of America COVID-19 Treatment Guidelines Panel.

Publications

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Shumaker AH, Bhimraj A, Bedimo R, Cheng VC, Chew KW, Daar ES, Glidden DV, Shafer RW, Tien PC, Baden LR, Cawcutt K, Chiotos K, Dzierba AL, Hardy EJ, Johnson S, Kim AY, MacBrayne C, Martin GS, Nadig N, Nakamura MM, Oliveira CR, Pearson JC, Riley L, Shoham S, Tebas P, Willis Z, Wolf J, Loveless J, Morgan RL, Falck-Ytter Y, Gandhi RT

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Nadig N, Bhimraj A, Cawcutt K, Chiotos K, Dzierba AL, Kim AY, Martin GS, Pearson JC, Shumaker AH, Baden LR, Bedimo R, Cheng VC, Chew KW, Daar ES, Glidden DV, Hardy EJ, Johnson S, MacBrayne C, Nakamura MM, Oliveira CR, Riley L, Shafer RW, Shoham S, Tebas P, Tien PC, Willis Z, Wolf J, Loveless J, Falck-Ytter Y, Morgan RL, Gandhi RT

Prevalence of chlamydial, gonococcal and syphilis positivity by anatomical site and sex via self-collected biospecimens using at-home testing kits among a large and diverse cohort of men and women enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in

Sexually transmitted infections

Mimiaga MJ, Tian J, Chiu I, Yonko EA, Noori G, Aziz N, Jamieson BD, Qian Y, Alcaide ML, Augenbraun M, Friedman MR, Kempf MC, Dionne-Odom J, D'Souza G, Edmonds A, Konkle-Parker D, French AL, Ofotokunc I, Palella FJ, Plankey MW, Sharma A, Tien PC, Ho K, Visconti AJ, Detels R

2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Bhimraj A, Falck-Ytter Y, Kim AY, Li JZ, Baden LR, Johnson S, Shafer RW, Shoham S, Tebas P, Bedimo R, Cheng VC, Chew KW, Chiotos K, Daar ES, Dzierba AL, Glidden DV, Hardy EJ, Martin GS, MacBrayne C, Nadig N, Nakamura MM, Shumaker AH, Tien P, Loveless J, Morgan RL, Gandhi RT

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Abatacept.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Nadig N, Bhimraj A, Cawcutt K, Chiotos K, Dzierba AL, Kim AY, Martin GS, Pearson JC, Shumaker AH, Baden LR, Bedimo R, Cheng VC, Chew KW, Daar ES, Glidden DV, Hardy EJ, Johnson S, Li JZ, MacBrayne C, Nakamura MM, Riley L, Shafer RW, Shoham S, Tebas P, Tien PC, Loveless J, Falck-Ytter Y, Morgan RL, Gandhi RT

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Infliximab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Nadig N, Bhimraj A, Cawcutt K, Chiotos K, Dzierba AL, Kim AY, Martin GS, Pearson JC, Shumaker AH, Baden LR, Bedimo R, Cheng VC, Chew KW, Daar ES, Glidden DV, Hardy EJ, Johnson S, Li JZ, MacBrayne C, Nakamura MM, Riley L, Shafer RW, Shoham S, Tebas P, Tien PC, Loveless J, Falck-Ytter Y, Morgan RL, Gandhi RT

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Pemivibart for Pre-exposure Prophylaxis, Vilobelimab for Critical Illness, and Abatacept or Infliximab for Severe or Critica

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Bhimraj A, Falck-Ytter Y, Baden LR, Bedimo R, Cawcutt K, Cheng VC, Chew KW, Chiotos K, Daar ES, Dzierba AL, Glidden DV, Hardy EJ, Johnson S, Kim AY, Li JZ, MacBrayne C, Martin GS, Nadig N, Nakamura MM, Pearson JC, Riley L, Shafer RW, Shoham S, Shumaker AH, Tebas P, Tien PC, Loveless J, Morgan RL, Gandhi RT

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Vilobelimab.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Nadig N, Bhimraj A, Cawcutt K, Chiotos K, Dzierba AL, Kim AY, Martin GS, Pearson JC, Shumaker AH, Baden LR, Bedimo R, Cheng VC, Chew KW, Daar ES, Glidden DV, Hardy EJ, Johnson S, Li JZ, MacBrayne C, Nakamura MM, Riley L, Shafer RW, Shoham S, Tebas P, Tien PC, Loveless J, Falck-Ytter Y, Morgan RL, Gandhi RT

Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Davy-Mendez T, Napravnik S, Hogan BC, Eron JJ, Gebo KA, Althoff KN, Moore RD, Silverberg MJ, Horberg MA, Gill MJ, Colasanti JA, Nijhawan A, Karris MY, Klein MB, Lang R, Lesko CR, Yendewa GA, Kirk GD, McGinnis KA, Berry SA, North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epi

In the Mismatch: Viral Suppression Despite Low Tenofovir-Diphosphate in Dried Blood Spots in the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Mann SC, Lykins D, Coyle RP, Witt MD, Kim EY, Macatangay B, Brown TT, Dionne JA, Alcaide M, Lahiri CD, Ramirez C, Dumond JB, D'Souza G, Cohen MH, Wilson TE, Kassaye S, Tien PC, Adedimeji AA, Ellison L, Brooks KM, Bushman LR, Anderson PL, MaWhinney S

Healthy Aging and the Gut Microbiome in People With and Without HIV.

The Journal of infectious diseases

Peters BA, Xue X, Hanna DB, Wang Y, Wang Z, Sharma A, Floris-Moore M, Konkle-Parker D, Alcaide ML, Sheth AN, Topper EF, Weber KM, Tien PC, Merenstein D, Vásquez E, Chen Y, Mimiaga MJ, Stosor V, Brown TT, Erlandson KM, Dillon SM, Elsayed NS, Usyk M, Sollecito CC, Kaplan RC, Burk RD, Qi Q

LIVE BIRTHS AND CARDIAC STRUCTURE AND FUNCTION IN WOMEN WITH AND WITHOUT HIV.

Journal of the American College of Cardiology

Vikasni Mohan, Yue Pan, Valeria Londoño, Yawen Lu, Nicholas Fonseca Nogueira, Weiqun Tong, Michelle Floris-Moore, Aruna Chandran, Yasmeen A. Golzar, Phyllis Tien, Anandi Sheth, Anna Emily Bortnick, Margaret Fischl, Maureen H. Lowery, Deborah Jones, Maria L Alcaide, Claudia A. Martinez

SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial).

Scientific reports

Sábato S, Benet S, Rogers AJ, Murray TA, Skeans M, Mothe B, Paredes R, Mourad A, Kiweewa F, Kamel D, Jain MK, Lutaakome J, Nalubega MG, Sebudde N, Mylonakis E, Braun DL, Hatlen T, Kimuli I, Kitko C, Mugerwa H, Kitonsa J, Kim K, Tien PC, Highbarger J, McCormack AL, Sanchez A, Murray DD, Babiker AG, Davey VJ, Files DC, Gelijns AC, Higgs ES, Kan VL, Matthews GV, Pett SL, Lane HC, Reilly C, Goodman AL, Lundgren JD, Moltó J, ACTIV-3/VATICO study group and the STRIVE Network

National Institutes of Health COVID-19 Treatment Guidelines Panel: Perspectives and Lessons Learned.

Annals of internal medicine

Gulick RM, Pau AK, Daar E, Evans L, Gandhi RT, Tebas P, Ridzon R, Masur H, Lane HC, NIH COVID-19 Treatment Guidelines Panel, Adimora AA, Baker J, Kreuziger LB, Bedimo R, Belperio P, Bhalla A, Burgess T, Campbell D, Cantrill S, Chew K, Chiotos K, Coopersmith C, Davey R, Dzierba A, Eisnor D, Eschenauer G, Francis J, Gallagher J, Glidden D, Goldenberg N, Grund B, Han A, Hardy E, Harrison C, Henderson L, Higgs E, Hinkson C, Hughes B, Johnson S, Keller M, Kim A, Knight R, Kuriakose S, Lennox J, Lerner A, Levy M, Li J, MacBrayne C, Martin G, Nadig N, Nason M, Patel P, Pavia A, Proschan M, Schulert G, Seam N, Sheikh V, Simpson S, Singh K, Swindells S, Tien P, Uyeki T, Waghmare A, Wolfe C, Yazdany J, Aberg J

HIV, HIV-specific Factors and Myocardial Disease in Women.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Kato Y, Ambale-Venkatesh B, Naveed M, Shitole SG, Peng Q, Levsky JM, Haramati LB, Ordovas K, Noworolski SM, Lee YJ, Kim RS, Lazar JM, Anastos K, Tien PC, Kaplan RC, Lima JAC, Kizer JR

Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection.

Nature communications

Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky SM, Witt MD, Post WS, Kossenkov A, Landay AL, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M

The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.

Journal of virology

Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL, MACS/WIHS combined cohort study (MWCSS)

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection.

bioRxiv : the preprint server for biology

Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky S, Witt M, Post WS, Kossenkov A, Landay A, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M

Lung Function in Women with and without HIV.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Wang RJ, Nouraie M, Kunisaki KM, Huang L, Tien PC, Anastos K, Bhandari N, Bhatt SP, Bolivar H, Cribbs SK, Foronjy R, Gange SJ, Lazarous D, Morris A, Drummond MB

HIV is associated with elevated FibroScan-AST (FAST) score.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Price JC, Ma Y, Kuniholm MH, Adimora AA, Fischl M, French AL, Golub ET, Konkle-Parker D, Minkoff H, Ofotokun I, Plankey M, Sharma A, Tien PC

Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Annals of internal medicine

Kuriakose S, Singh K, Pau AK, Daar E, Gandhi R, Tebas P, Evans L, Gulick RM, Lane HC, Masur H, NIH COVID-19 Treatment Guidelines Panel , Aberg JA, Adimora AA, Baker J, Kreuziger LB, Bedimo R, Belperio PS, Cantrill SV, Coopersmith CM, Davis SL, Dzierba AL, Gallagher JJ, Glidden DV, Grund B, Hardy EJ, Hinkson C, Hughes BL, Johnson S, Keller MJ, Kim AY, Lennox JL, Levy MM, Li JZ, Martin GS, Naggie S, Pavia AT, Seam N, Simpson SQ, Swindells S, Tien P, Waghmare AA, Wilson KC, Yazdany J, Zachariah P, Campbell DM, Harrison C, Burgess T, Francis J, Sheikh V, Uyeki TM, Walker R, Brooks JT, Ortiz LB, Davey RT, Doepel LK, Eisinger RW, Han A, Higgs ES, Nason MC, Crew P, Lerner AM, Lund C, Worthington C

HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa.

Global health, epidemiology and genomics

Ekoru K, Young EH, Dillon DG, Gurdasani D, Stehouwer N, Faurholt-Jepsen D, Levitt NS, Crowther NJ, Nyirenda M, Njelekela MA, Ramaiya K, Nyan O, Adewole OO, Anastos K, Compostella C, Dave JA, Fourie CM, Friis H, Kruger IM, Longenecker CT, Maher DP, Mutimura E, Ndhlovu CE, Praygod G, Pefura Yone EW, Pujades-Rodriguez M, Range N, Sani MU, Sanusi M, Schutte AE, Sliwa K, Tien PC, Vorster EH, Walsh C, Gareta D, Mashili F, Sobngwi E, Adebamowo C, Kamali A, Seeley J, Smeeth L, Pillay D, Motala AA, Kaleebu P, Sandhu MS

Reply.

Hepatology (Baltimore, Md.)

Price JC, Tien PC

Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis.

International journal of epidemiology

Dillon DG, Gurdasani D, Riha J, Ekoru K, Asiki G, Mayanja BN, Levitt NS, Crowther NJ, Nyirenda M, Njelekela M, Ramaiya K, Nyan O, Adewole OO, Anastos K, Azzoni L, Boom WH, Compostella C, Dave JA, Dawood H, Erikstrup C, Fourie CM, Friis H, Kruger A, Idoko JA, Longenecker CT, Mbondi S, Mukaya JE, Mutimura E, Ndhlovu CE, Praygod G, Pefura Yone EW, Pujades-Rodriguez M, Range N, Sani MU, Schutte AE, Sliwa K, Tien PC, Vorster EH, Walsh C, Zinyama R, Mashili F, Sobngwi E, Adebamowo C, Kamali A, Seeley J, Young EH, Smeeth L, Motala AA, Kaleebu P, Sandhu MS

Primary subtype C HIV-1 infection in Harare, Zimbabwe.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association

Tien PC, Chiu T, Latif A, Ray S, Batra M, Contag CH, Zejena L, Mbizvo M, Delwart EL, Mullins JI, Katzenstein DA