Midori Kato-Maeda, MD, MA

ADJ PROF-HCOMP
M_MED-ZSFG-PULM
[email protected]

Research Interests

Dr. Kato-Maeda’s research activities focuses on 1) transmission of Mycobacterium tuberculosis (MTB), 2) drug- resistant tuberculosis, and 3) tuberculosis diagnosis.

Dr. Kato-Maeda, along with her U.S. and international collaborators, established community-based studies in San Francisco, Tanzania, and Uganda to study the transmission dynamics of MTB, using molecular epidemiology tools to identify patient and environmental factors that can be modified to decrease transmission of MTB, and to identify populations that have a high risk of infection. These studies have resulted in guided tuberculosis control interventions.

Another goal of her research is to determine the impact of bacterial characteristics on the transmission dynamics of MTB. Dr. Kato-Maeda and her collaborators developed the method to classify MTB in phylogenetic sound groups. This classification revolutionized the study of the impact of bacterial factors on the clinical and epidemiological phenotypes of this disease. They identified lineages of MTB that cause more secondary cases of tuberculosis, suggesting that bacterial factors contribute to the pathogenicity of MTB. Importantly, based on these studies, they created and published a collection of well-characterized clinical MTB strains representing different lineages which will be used by the global TB research community for in vitro and in animal studies. These research projects have resulted in a biobank with more than 3,000 clinical isolates of MTB and MTB DNA and the associated metadata, which they have used for new projects with collaborators inside and outside of UCSF.

Dr. Kato-Maeda’s studies in drug-resistant tuberculosis are focused on identifying novel genomic factors that govern drug-resistant tuberculosis and the impact of the introduction of novel drugs on the epidemiology of drug-resistant tuberculosis. These studies are being performed in collaboration with a strong team of multidisciplinary researchers from the Philippines and Japan. As a result of this project, they have created a research-specific biobank with more than 900 isolates of drug resistant MTB.

Dr. Kato-Maeda is a member of the Rapid Research for Diagnostics Development in TB Network (R2D2 TB Network), an initiative led by Drs. Adithya Cattamanchi and Payam Nahid at UCSF. The network involves clinical sites in the Philippines, Vietnam, Uganda, South Africa, and India. Dr. Kato-Maeda leads the specimen acquisition, processing, storage, shipping, and distribution as well as the quality assurance and quality control activities to ensure procedures are followed and performed to standard to ensure good quality specimens and contribute to the discussions with the developers about their assays.

Dr. Kato-Maeda’s unique expertise in mycobacteriology and MTB genomics has also enabled her to be an integral part of projects led by other members of the UCSF Center for Tuberculosis (https://tb.ucsf.edu/), and her laboratory serves as their core lab.

Dr. Kato-Maeda’s research projects have always been conducive to training, transfer of technology, and capacity building for our international collaborators.

Publications

Impact of heteroresistance on treatment outcomes of people with drug-resistant TB.

IJTLD open

Crowder R, Kato-Maeda M, Schwem B, Dela Tonga A, Geocaniga-Gaviola DM, Lopez E, Valdez CL, Lim AR, Hunat N, Sedusta AG, Sacopon CA, Atienza GAM, Bulag E, Lim D, Bascuña J, Shah K, Basillio RP, Berger CA, Lopez MCDP, Sen S, Allender C, Folkerts M, Karaoz U, Brodie E, Mitarai S, Garfin AMC, Ama MC, Engelthaler DM, Cattamanchi A, Destura R

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania.

PLoS pathogens

Zwyer M, Rutaihwa LK, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schm?lling L, Borrell S, Reinhard M, D?tsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong BC, Kato-Maeda M, Jugheli L, Ernst JD, Niemann S, Jeljeli L, Ballif M, Egger M, Rakotosamimanana N, Yeboah-Manu D, Asare P, Malla B, Dou HY, Zetola N, Wilkinson RJ, Cox H, Carter EJ, Gnokoro J, Yotebieng M, Gotuzzo E, Abimiku A, Avihingsanon A, Xu ZM, Fellay J, Portevin D, Reither K, Stadler T, Gagneux S, Brites D

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim.

F1000Research

Fabrizio Menardo, Liliana K. Rutaihwa, Michaela Zwyer, Sonia Borrell, Iñaki Comas, Emilyn Costa Conceição, Mireia Coscolla, Helen Cox, Moses Joloba, Horng-Yunn Dou, Julia Feldmann, Lukas Fenner, Janet Fyfe, Qian Gao, Darío García de Viedma, Alberto L. Garcia-Basteiro, Sebastian M. Gygli, Jerry Hella, Hellen Hiza, Levan Jugheli, Lujeko Kamwela, Midori Kato-Maeda, Qingyun Liu, Serej D. Ley, Chloe Loiseau, Surakameth Mahasirimongkol, Bijaya Malla, Prasit Palittapongarnpim, Niaina Rakotosamimanana, Voahangy Rasolofo, Miriam Reinhard, Klaus Reither, Mohamed Sasamalo, Rafael Silva Duarte, Christophe Sola, Philip Suffys, Karla Valeria Batista Lima, Dorothy Yeboah-Manu, Christian Beisel, Daniela Brites, Sebastien Gagneux

Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim.

F1000Research

Menardo F, Rutaihwa LK, Zwyer M, Borrell S, Comas I, Conceição EC, Coscolla M, Cox H, Joloba M, Dou HY, Feldmann J, Fenner L, Fyfe J, Gao Q, García de Viedma D, Garcia-Basteiro AL, Gygli SM, Hella J, Hiza H, Jugheli L, Kamwela L, Kato-Maeda M, Liu Q, Ley SD, Loiseau C, Mahasirimongkol S, Malla B, Palittapongarnpim P, Rakotosamimanana N, Rasolofo V, Reinhard M, Reither K, Sasamalo M, Silva Duarte R, Sola C, Suffys P, Batista Lima KV, Yeboah-Manu D, Beisel C, Brites D, Gagneux S

History of tuberculosis.

Tuberculosis

Robert Loddenkemper, John F. Murray, Christoph Gradmann, Philip C. Hopewell, Midori Kato-Maeda

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Nature genetics

Stucki D, Brites D, Jeljeli L, Coscolla M, Liu Q, Trauner A, Fenner L, Rutaihwa L, Borrell S, Luo T, Gao Q, Kato-Maeda M, Ballif M, Egger M, Macedo R, Mardassi H, Moreno M, Tudo Vilanova G, Fyfe J, Globan M, Thomas J, Jamieson F, Guthrie JL, Asante-Poku A, Yeboah-Manu D, Wampande E, Ssengooba W, Joloba M, Henry Boom W, Basu I, Bower J, Saraiva M, Vaconcellos SEG, Suffys P, Koch A, Wilkinson R, Gail-Bekker L, Malla B, Ley SD, Beck HP, de Jong BC, Toit K, Sanchez-Padilla E, Bonnet M, Gil-Brusola A, Frank M, Penlap Beng VN, Eisenach K, Alani I, Wangui Ndung'u P, Revathi G, Gehre F, Akter S, Ntoumi F, Stewart-Isherwood L, Ntinginya NE, Rachow A, Hoelscher M, Cirillo DM, Skenders G, Hoffner S, Bakonyte D, Stakenas P, Diel R, Crudu V, Moldovan O, Al-Hajoj S, Otero L, Barletta F, Jane Carter E, Diero L, Supply P, Comas I, Niemann S, Gagneux S

35 Tuberculosis.

Murray and Nadel\u0027s Textbook of Respiratory Medicine

Philip C. Hopewell, Midori Kato-Maeda, Joel D. Ernst

Screening for tuberculosis in pregnancy.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Navarro-Alvarez S, Bobadilla del Valle M, Kato-Maeda M